In all my years of living full-time in my chosen gender, the biggest frustration was probably my voice. While not exactly basso profundo, it still gave off a definite "male" signal to others in the earliest years. Yet, paradoxically, I can remember being called "ma'am" on the phone on many occasions pre-transition. (The answer, I realized many years later, was that my telephone voice had a certain lilt that read as female to those on the other end, but I didn't know about modulation at the time. So it was a complete mystery to me).