The transcript of the video is also available, linked from THR article, but it's worth watching the video from about 5 minutes in, because she's quite charming.

My favorite bits from the video:

I was valedictorian of my class and Mr. Henderson my teacher informed me that I got to give a speech as a result of being valedictorian. I didn’t think this was a very big deal. I’m not sure about this little award thing, either, but. Being painfully shy I declined. I said, “Let someone else be valedictorian.” He didn’t like this answer. He said, “That’s not how this works.” He said he understood how I felt, no one likes giving speeches -- why do we do it? -- but sometimes I had to think not just about myself but about my class and my parents, who would be very proud of me, he said. There are some things that we have to do for ourselves, but there are other things that we have to do for other people.

and

I am completely horrified by the “talk show,” the interrogation and confession format, the weeping, the tears of the host, whose sympathy underscores the inherent tragedy of my life as a transgender person. And this moment fulfilling the cathartic arc of rejection to acceptance without ever interrogating the pathology of a society that refuses to acknowledge the spectrum of gender in the exact same blind way they have refused to see a spectrum of race or sexuality.

and

After school I go to the nearby Burger King and write a suicide note. It ends up being over four pages. I’m a little talkative. But it was addressed to my parents and I really wanted to convince them that it wasn’t their fault, it was just that I didn’t belong. I cry a lot as I write this note, but the staff at Burger King has seen it all before, and they seem immune.

I love love love Cloud Atlas the book, but I didn't like the movie much (I saw it in Toronto a month ago). For all that, my respect for Ms Wachowski has gone up quite a lot. She's got talent as a speaker. And she's got dignity.