hormone question

I recently (a little more than two weeks ago) started taking 1mg of Estradiol. (Evidently my body knew something was up in advance so my hormone levels weren't that far off to what they should be for transitioning). I notice lately that I've been having headaches. Not really headaches, but cerebral discomfort. Is this normal? I was thinking maybe with brain chemistry changing and all. I'm not in any pain, just concerned.